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We identify somatically acquired elements exhibiting germline allelic biases and non-coding somatic mutations creating new promoters.
We analyzed curves of discharge frequency, F, plotted against somatically injected current.
Li, Z. et al. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1.
Among all somatically mutated genes, CREBBP mutations were most significantly enriched within the earliest inferable progenitor.
Raine, K. M. et al. cgpPindel: identifying somatically acquired insertion and deletion events from paired end sequencing.
Raine, K. M. et al. ascatNgs: identifying somatically acquired copy number alterations from whole-genome sequencing data.
Interestingly, nearly half of somatically mutated genes fall below that range (shown for breast cancer in Fig. 4b,c).
Clinical annotation data, DNA copy number data, and somatically called mutations are available as Supplementary Data 1 3, respectively.
Very aware.
Krishnamurty, A.T. et al. Somatically hypermutated Plasmodium-specific IgM+ memory B cells are rapid, plastic, early responders upon malaria rechallenge.
A major aim of cancer genomics is to pinpoint which somatically mutated genes are involved in tumor initiation and progression.
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