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Our data suggest two independent mechanisms by which Aβ causes neurodegeneration: a neuritic type and a somatic type.
The somatic type of neurodegeneration shows mitochondrial alterations in the neuronal soma but no changes in neurite morphology of non-necrotic and non-apoptotic cells.
Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type (DDST).
Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type.
Two classes of 5S rDNA were also observed in Xenopus; the first was expressed in somatic cells and the second, which was derived from the somatic type by gene duplication, was expressed in oocytes [ 21].
Although the appearance of the dendrites and axons was, except for the Aβ threads, morphologically normal and no synapse loss was observed, mitochondrial changes in nerve cell somata represented early signs of a somatic type of neurodegeneration.
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The somatic type-2 deletion identified in tumor P082-1N in this study has to be considered as a second-hit mutation that leads to the loss of the wild-type NF1 allele.
In these cases, we performed several diagnostic PCR reactions, as described by Steinmann et al. [ 2007], to identify somatic type-1 or type-2 NF1 deletions with breakpoints either in the NF1-REPs or in the SUZ12 sequences (see Fig. 1B).
Almost all Ff-hiPSCs have differentiation potential, and can differentiate into several kinds of somatic-type cells.
If the Xist domain localises together with the MS4 domain, then the X inactivation pattern is somatic-type, in which the M. rossiaemeridionalis X is preferentially inactivated.
When these vasa-positive cells move to region-3 germarium, the H3-K9 taskethylatisg transferrednsferred to a combination of dSETDB1 and SU VAR 3 9, as both enzymes act cooperatively in all other somatic-type cells of the germarium.
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