There is a concern that the reprogramming factors used by iPS cell technology may accelerate the rate of somatic mutation, adding noise to assays of single mutations; fortunately, Ira's preliminary results suggest that this effect is likely to be modest.
Pennebaker and Skelton (1981) showed that giving healthy subjects expectations about a somatic symptom (that a noise would change body temperature) caused them selectively to monitor somatic information that was consistent with the expectation and to disregard information that was inconsistent.
Compared to adults, younger children tend to describe their reactions to noise in a somatic way.
Noise sensitivity has somatic and psychological components and has been linked to hypertension, stress, depression, phobias, and hostility (Heinonen-Guzejev et al. 2004; Stansfeld 1992).
An important finding is that children, compared to adults, seem to have a tendency to describe reaction to noise in a somatic way: they literally feel the noise in their body, especially in the head, heart and tummy.
Thus, an increase in the sequence coverage leads to an increase in the detection sensitivity of somatic variants by decreasing the background noise [ 28- 32].
Somatic firing is modeled as an escape noise process with an instantaneous rate function ϕ S ( U ( t ; Y, Z ) ) where ϕ S ( x ) = q S e β S x (6).
In addition to confirming a central role for OCT4 and SOX2 in reprogramming by defined factors, our model also suggests that non-specific widespread amplification of transcriptional noise may aid reprogramming of somatic cells to a pluripotent state.
Sex-biased autosomal genes tended to be expressed at lower levels and in fewer tissues than unbiased gene targets, and autosomal somatic sex-biased genes had more expression noise than similar unbiased genes.
