Often it is attributed to mosaicism resulting from de novo somatic events.
The finding that large fluctuations in the CR-estimator can arise from rare somatic events, confirms the suspicion in Section 4.2 that recasting Equation 20 as a sampling procedure can lead to problems.
We postulated that, if these somatic events are genetically redundant, then having the K-ras mutation will confer the mutant EGFR transcriptional profile.
Some of the somatic events involved in lung cancer have been well characterized, but some of them remain unknown [2], [3].
This large-scale multi-center study examined germline DNA markers and their contributions to somatic events, especially susceptibility to DNA methylation in CRC.
Nonetheless, most processes with nominally significant P values were those previously highlighted, which are associated with somatic events [26], [27] (Table S1).
Moreover, a survey of monozygotic twins yielded a discordance rate of 92%, suggesting that somatic events, genetic or epigenetic, probably play an important role in the etiology of CHTD.
These simple criteria were designed to control for the removal of truly somatic events, such that a de novo duplication observed in a prior study would not invalidate a tumor-associated deletion at the same locus.
Previously, analysis of the CGEMS GWAS dataset using the lowest genotypic P value per gene locus suggested true associations in genes annotated with Gene Ontology (GO) biological process terms linked to somatic events [26], [27].
That the BAK1 sequence variants are due to somatic events, which they dismiss as highly unlikely.
It is unlikely that these somatic events are necessary for neurofibroma growth.
