Sentence examples for somatic errors from inspiring English sources

Somatic errors can only accumulate within stem cells because non-stem cells and their errors are lost within days from normal crypt cell differentiation and migration [ 4, 5].

The etiology of such age-related methylation is uncertain, but one possible mechanism is random somatic errors during DNA replication [ 4].

Thus, while a subset of the LDGs has an increased frequency of somatic errors including duplications, deletions, and LOH, specific mutations in either the JAK2 kinase or Flt3 kinase that have been associated with myeloproliferative disorders or acute myeloid leukemia were not detected.

The stochastic nature of somatic epigenetic errors requires an algorithm for interpretation, which essentially translates the sophisticated methods used to extract ancestry from species genomes to reconstruct somatic cell histories.

or endogenous (primarily transposons) agents, and/or that such tissue is compromised in the repair of somatic replication error.

Williams, S. R. & Mitchell, S. J. Direct measurement of somatic voltage clamp errors in central neurons.

These variants are expected to consist of (in descending order of frequency) inherited polymorphisms, somatic mutations, sequencing errors and actual differences between RNA and DNA (eg, RNA editing and polyadenylation).

The overwhelming majority of sSNVs involve C>T transitions at CpG sites, with some differences in mutation patterns between CLL with mutations in the Ig heavy variable region (IGHV-mutated) and CLL lacking IGHV mutations (IGHV-unmutated), suggestive of the involvement of aberrant somatic hypermutation with error-prone repair [ 33].

Based on the error rate map, we could formulate a discrimination pipeline of somatic mosaicism from sequencing errors and thereby detect new somatic mosaicism in mutation-negative CINCA/NOMID patients, whose somatic mutations were subsequently confirmed by subcloning and Sanger sequencing.

In somatic cells, chromosome segregation errors during mitosis may contribute to cancer development and progression [ 51].

The inherent problem of such analysis is distinguishing somatic mutations from sequencing errors and SNPs.