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The definition of individual terminal varicosities was so sharp and detailed that it was routinely practical to examine the relationship of putative vagal efferent contacts (by the criteria of high magnification light microscopy) with the dendritic and somatic architecture of counterstained neurons in the myenteric plexus.
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Dissection of putative mechanisms mediating constraints exerted by the genome architecture on somatic cancer evolution may provide an algorithm for understanding, predicting and modifying somatic cancer evolution in individual patients.
Dissection of putative mechanisms mediating constraints exerted by the genome architecture on somatic cancer evolution may provide an algorithm for understanding and predicting as well as modifying somatic cancer evolution in individual patients.
Correlations between life history traits suggest a common genetic architecture or somatic cost of certain traits on others.
In a first step, a conceptual framework will be developed which defines and systemizes putative constraints of the genome architecture on somatic cancer evolution.
Constraints of the genome architecture on somatic tumor cell evolution may, therefore, constitute an alternative explanation of stem cell-like behavior of cancer cells.
Finally, we investigate embryonic stem cells (ESCs) and senescent cells and find a fundamentally opposing local architecture with somatic cells representing an intermediate state.
Therefore, it would be valuable to conduct a global analysis of the epigenome architecture of somatic embryos in order to understand the expression patterns of diverse embryogenesis related genes.
While these pioneering studies have established the first architecture of somatic mutation patterns in pan-cancers, a detailed and deep exploration of mutational profiles within and between cancer types has not yet been performed.
The systems approach postulates three classes of lineage selection effects of the genome architecture on somatic cancer evolution: i) effects mediated by changes of fitness of cells of cancer lineage, ii) effects mediated by changes of mutation probabilities and iii) effects mediated by changes of gene designation and physical and functional genome redundancy.
It postulates three classes of lineage selection effects of the genome architecture on somatic cancer evolution: i) effects mediated by changes of fitness of cells of cancer lineage, ii) effects mediated by changes of mutation probabilities and iii) effects mediated by changes of gene designation and by changes of physical and functional genome redundancy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com