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We use a = 0.5 for the NMDA-spike strength in Equation 5, so that just 2-3 concurrent NMDA-spikes are likely to generate a somarec action potentialikely
We will consider synaptic plasticity in the context of reinforcement learning, where the somatic action potentials control the delivery of an external reward signal.
As a consequence, the CR-rules can now support reinforcement learning also when the precise timing of somatic action potentials is crucial for reward delivery.
Using this rule, NMDA-zones learn as independent agents which are oblivious of their interaction in generating somatic action potentials, with the external reward signal being the only mechanism for coordinating plasticity between the zones.
Note that the remaining contribution B k has as factor β ( y ∖ k ), a term which explicitly reflects how a NMDA-event at time t k contributes to the generation of somatic action potentials.
In real neurons, the temporal precision is likely to result from the interaction of NMDA-spikes with AMPA-releases, with the NMDA-spikes determining periods of heightened excitability during which AMPA-releases can easily trigger a precise somatic action potential.
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We also tested the effects of low TTX on the responses to low-frequency or high-frequency (5 stimuli at 100 Hz) activation of the PP, while using localized application of a higher concentration of TTX (10 µM in the application pipette) to the vicinity of the soma and proximal axons ('Materials and methods'; Figure 1A) in order to prevent somatic or axonal action potential initiation.
Contrary to its action in somatic cells, LIF maintains the self-renewal and pluripotency of ES cells through the activation of the canonical JAK/STAT3 pathway.
It is believed that certain of these processes are brought about by the action of somatic stem cells.
These alterations are attributed to changes in vascular permeability due to the inflammatory process and the damage of epithelial cells that are responsible for the synthesis of milk components as well as changes in the enzymatic action of somatic cells or microorganisms in the infected mammary gland [ 6].
Triptans have been shown to reduce nociceptive activation in animal studies through actions on somatic, vascular and dural afferents, and central trigeminal and solitary nucleus neurons [37 40].
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