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After the solvent diffusion procedure, the suspension was cross-linked using 25% (v/v) glutaraldehyde solution as a cross-linking agent.
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For this reason, even in the literature there are some preparation procedures [e.g. high pressure homogenisation (HPH), microemulsion, solvent diffusion, high shear homogenisation coupled with ultrasound technique], the most used technique for production of SLNs is HPH which allows obtaining of a narrow size distribution of nanoparticles.
The hybrid nanoparticles were prepared using emulsion solvent diffusion method.
The PLA PEG blank nanoparticles were prepared by modified solvent diffusion method.
The PLA PEG blank nanoparticles were produced by modified solvent diffusion method [16].
In this work, we developed PLA-based Doc-loaded oily NCs by solvent diffusion method.
Nanoparticles were prepared by solvent diffusion method with poloxamer 188 as stabiliser.
Nanocarriers were prepared using solvent diffusion method by applying 23 factorial design.
Microsponges containing FLB and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method.
Drug-loaded PLGA poloxamer nanoparticles were prepared by a modified solvent diffusion technique.
The double emulsion solvent diffusion (DESD) method, designed for hydrophilic compounds, yielded similar encapsulation efficiency (80%).
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