A greater understanding of the cellular mechanisms involved allows design-based solutions for rationale development of safe, effective and clinically relevant polyplex-based RNAi drugs.
When working with policymakers to craft legislation, be proactive in offering your ideas or insights; be prepared to answer questions; and present solutions and a rationale to support those solutions.
Rationale for action/possible solutions: e.g. rationale for health promotion strategies based on evidence that hand washing with soap helps prevent diarrhoeal diseases [ 37].
During the Conclusion Phase, the students share their solutions; discuss their rationale and present their learning outcomes (typically in the form of a presentation); reflect on the new knowledge, conceptual understanding and overall learning experience; conduct peer- and self-assessment; and provide suggestions for improving the PBL curriculum in relation to the learning goals and expectations.
Michael Pistorio, Des Plaines, Ill.: While I completely agree that it is a travesty for Americans to be devoid of a national health care solution, I question the rationale of comparing the costs of an American system to that of a foreign system.
Even if the requisite gains in fuel-cell technology are achieved, he says, the fuel-cell cars of the future should run instead on methanol, which has a higher energy-density than hydrogen and can be stored and transported much more easily.Furthermore, steam reformation of natural gas is far from a zero-emissions solution, undermining the whole rationale of hydrogen cars in the first place.
We propose a hybrid solution approach incorporating the rationale of two well-known metaheuristics which have proven to be effective for routing problem variants, namely tabu search and guided local search.
"It's a messy solution and lacks a clear rationale," Turnbull told the public administration select committee last week.
Unfortunately, the presentation of a final solution does not reveal the rationale for decisions made during the design process.
The proposed solution for explicating the design rationale makes it possible for others to understand the decisions made and thereby supports replicating experiments or reusing parts of the design rationale.
