Sentence examples for solubility limitations from inspiring English sources
Novel formulations that overcome the solubility limitations of poorly water soluble drugs (PWSD) are becoming ever more critical to a drug development process inundated with these compounds.
With the recent advent of nanotechnology for pharmaceutical applications, drug particle engineering is the focus of increasing interest as a viable approach for overcoming solubility limitations of poorly water-soluble drugs.
The PBD responses reveal unanticipated chemical effects: multiple complexes in the Ag system and solubility limitations in the Sn system, neither of which is evident from the electrochemical or QCM responses.
It is a principal objective of this work to design a scCO2 strategy to reduce 5-Fu solubility limitations in its homogeneous distribution into a PCL scaffold through the design of an innovative processing method.
This method can easily disperse the CNTs in the polymer; however, it is not suitable for mass production due to its high cost, toxicity of the solvent, and solubility limitations of the polymer in the solvent.
The results revealed, that the organic method suffers from enzyme solubility limitations at given conditions.
Here, multilayer architecture combining Ti0.52Al0.48N and Al0.66Ti0.34N is used to increase the solubility limitation of c-Ti1 − xAlXN by controlling their coherent growth in order to optimize the properties of Ti Al N coating.
The addition of Ta to Ti-Al-N coatings with chemical compositions right at the border for the face centered cubic metastable solubility limitation, can promote the formation of undesired hexagonal phases.
We suggest that due to the low binding affinities for the 1 1 BMP2 ActR-IIB interaction (approximately 3 μM, see table 2), significantly high levels of ligand specifically bound to monomeric type II receptors cannot be achieved due to increased unspecific interactions and solubility limitation of the BMP ligands.
The salt formation of the API is widely adopted strategy for improving its solubility; but limitation of the process is its inapplicability to nonionizable drugs and also its stability concerns in solid state [ 7].
The unmodified scFv described in this study was not analysed as it is an unlikely candidate for further development due to the afore-mentioned solubility and stability limitations during recombinant production.
