A SD with a drug-to-polymer ratio of 1 : 6 had a significantly enhanced solubility enhancement compared with ATR.
The solubility enhancement of poorly soluble drugs, required for the dissolution studies from drug formulation, can be achieved by using surfactants.
For solubility enhancement of poorly water-soluble drugs, preparation of the solid dispersion or the complexation with proper drugs or excipients should be a promising approach.
PVP is used as binders in pharmaceutical tablets and as additives in batteries, ceramics, fiberglass, inks, and inkjet paper; this polymer is also used in the production of membranes, such as dialysis and water purification filters, as well as in the solubility enhancement of poorly water-soluble drugs [25, 26].
CR-ASD formulations of poorly water-soluble drugs should comprise both functions of solubility enhancement and modulation of the rate of drug release.
Meanwhile, the roles of other parameters such as protein hydrophilicity in solubility enhancement were discussed, a guideline to design or search an optimum protein solubility enhancer was also proposed.
Dendrimers are reported as carriers for solubility enhancement, for therapeutic delivery, to reduce the cytotoxicity of the drug, to enhance stability of the drug, and for increasing bioavailability of drugs in oral administration.
Drug-phospholipid complexation may thus be a promising strategy for solubility enhancement of bioactive phytoconstituents.
Solid dispersion prepared by simple fusion method could be an option for itraconazole solubility enhancement.
Solubility enhancement was observed for all lipid systems, but to different extents.
ME applications include taste masking, solid-state stability enhancement, sustained drug release and solubility enhancement.
