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The high concentration of solid drug nanoparticles provided additional cake stability.
Roller compaction is a dry granulation process for manufacturing solid drug formulations.
A concentration-dependent effective diffusion coefficient was used to count increased porosity as the solid drug had dissolved.
Consistent production of solid drug materials of desired particle and crystallographic morphologies under cGMP conditions is a frequent challenge to pharmaceutical researchers.
Another singular feature is related to the friendly manipulation of a broad variety of spatially non-uniform drug loading, including size distribution of solid drug particles.
The release of the drug can be dependent on a number of factors such as the solubility, diffusivity, dissolution rate and distribution of the solid drug in the matrix.
Similar(42)
Compressed CO2 foaming allows for obtaining porous solid drug-loaded scaffolds for regenerative medicine under mild conditions and in the absence of organic solvents.
Theoretical Analysis of Rate of Release of Solid Drugs Dispersed in Solid Matrices.
The poor dissolution behaviour of solid drugs in biological environment leads to a low bioavailability.
Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers.
Chemists and engineers involved in the production of solid drugs have to deal with difficult new challenges, including the on-line mastery of the crystal habits and size distribution or the control of polymorphic transitions.
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