Previously, a retrospective trial comparing 25 patients receving intraarterial GC with 35 patients solely undergoing cystectomy has recently been published by Jiang et al. [ 49] The data from the retrospective study is promising as the HR for 1-year survival dropped to 0.18 (p = 0.04) in the adjuvant treatment arm with the most common adverse effect being transient myelosuppresion (40%) [ 49].
Most other benzodiazepine agents undergo metabolism solely or partially through CYP3A4, and thus concentrations may be increased by DAAs via CYP3A4 inhibition.
This last sample came from the only patient who underwent PM solely because of family history, she was neither a known BRCA mutation carrier nor did she have a personal history of breast cancer.
There were too few persistent AF subjects (n=8) undergoing solely PVI by RFA as a comparison group.
In terms of the representativeness of our cohort, the fact that we drew data solely from patients undergoing inpatient rehabilitation in Germany is also a limitation.
School-aged children and adolescents, who were more likely to have no or less typical CD symptoms, might also be more likely to undergo CD screening solely because of positive family members with CD compared with the younger children.
At present, it is not clear whether proliferating cardiomyocytes arise solely from resting cardiomyocytes, which might undergo partial de-differentiation or re-programming, or also from dedicated cardiac stem cells that are able to replace lost cardiac tissue.
Tumor cells, which often lack wild-type p53, are known to depend solely on the G2 arrest and to undergo mitosis with DNA breaks; this process is known as adaptation [ 30].
We have recently demonstrated that T cell HuR can undergo rapid nuclear-to-cytoplasmic translocation solely by engagement of LFA-1 with its ligand ICAM-1 [3].
It has been estimated that the viral burst size in case of influenza, in one cycle of replication, is about 1000 [42], and thus influenza virus should undergo ∼1000 rounds of genome replication solely by viral RNA polymerase.
