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The concept was also applied to G protein coupled receptors (GPCRs) where receptors that are solely activated by synthetic ligands (RASSL) were designed.
The contrast of (clear − rot) solely activated the left anterior STS.
MEF2C also represses the expression of MSX1, which is solely activated by BMP2 stimulus and activates COL2A1 according to the prior knowledge [ 27].
P2X receptors are a family of widely expressed ligand-gated, calcium-permeable cationic channels which are solely activated by extracellular adenosine triphosphate (ATP) in the body.
Interestingly, the mechanical hyperalgesia was not corrected by ivabradine (Fig 8C) suggesting that HCN channels are probably more prominent in monomodal nociceptors solely activated by cold.
VlPr neurons are, on the other hand, almost solely activated by repellent odors, which do hardly activate iPNs and therefore do not induce a strong inhibition to vlPr neurons.
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In contrast, receptor mutants Y292F and Y302F showed impaired ability to recruit β-arrestin in response to Sar1-Ile4-Ile8 (SII) ang II, a ligand solely activating the β-arrestin pathway.
In some breast cancer cell lines, FXa may solely activate PAR-2 [ 68].
Also Rad50 in the model is a subunit of the MRN complex, which solely activates ATM.
As Mre11 in the model is a subunit of the MRN complex, which solely activates ATM, the blocked pathways are the same as in the Ataxia telangiectasia simulation.
Moreover, we suspect that courtship song representation at the level of second-order neurons involves multiple neuronal cell types and solely activating aPN1 neurons is not sufficient to mimic a fictive courtship song stimulus.
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