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Whether Krm proteins solely act as antagonists of Wnt signalling is however questionable, since a positive influence on Lrp6-dependent Wnt signaling has been described for Krm2, which is possibly mediated through an interaction with Wnt signaling activators of the Rspo family [36], [37].
It is unlikely that Dkk-1 can solely act as a mitogen, but its presence at a critical threshold may serve as a checkpoint that permits proliferation of OS cells.
Our observation that D2O significantly stimulates transcription in the cell-free assay and 2(b)) is surprising as it indicates that D2O does not solely act as a decelerator of protein activity but rather can accelerate a complex process like DNA transcription and thus increase the yield of mRNA.
Although initially the RS domain was proposed to solely act as a protein protein interaction domain, it was later revealed that it also acts to contact the pre-mRNA (Shen and Green, 2004; Shen et al., 2004; Hertel and Graveley, 2005).
In this regard, our studies provide an additional layer of regulatory complexity, and support the idea that mRNAs, which are typically thought to solely act as the template for protein translation, can also serve as regulatory RNAs, independent of their protein-coding capacity.
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At present, it is not clear whether synphilin-1 triggers cytotoxicity by itself or solely acts as an accelerator that boosts the cellular stress responses induced by its interaction partner α-Syn.
At present, these "bath salts" are not readily classified with respect to their pharmacological mechanism of action: mephedrone is believed to be a substrate/releaser while MDPV solely acts as an uptake inhibitor.
Based on the observation that the circadian rhythms persist in the elf3-1 mutant, it was proposed that ELF3 solely acts as a light zeitnehmer, or timekeeper, and that it is not a required component of the oscillator.
A broker is not subject to the act as long as his advice is "solely incidental to the conduct of his business as a broker" and he does not receive "special compensation" for advice.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com