However, the formation of nemaline bodies can not only be caused by the presence of mutant actin, and neither can the accumulation of actin in the cytoplasm be the sole cause of muscle weakness, since loss of ACTA1 also results in the disease [ 32].
Yet this weakness is only relative; his sole defining trait in Jackson's widely-lauded The Fellowship of the Ring is a heroic desire to save his homeland.
For example, while services protecting vulnerable children and adults are being severely cut, at speed, we are fed a story – by politicians and sections of the media – of managerial weakness as the sole reason for failure.
Finally, hypalgesia of the lateral foot and sole [ 16, 21]; motor weakness of the gastrocnemius, flexor hallucis longus, and flexor digitorum longus muscles; and a reduced or absent Achilles tendon reflex were assessed as a first sacral (S1) radiculopathy.
Some traders, he said, were using what they called "predatory algorithms," whose sole purpose is to exploit a weakness in some other trader's algorithm and get it to make an unprofitable trade.
The patient presented with proximal muscle weakness, dysphagia, palms and soles rash and elevated serum levels of muscle enzymes, with liver and myocardial involvement.
He added that his sole objective this weekend was to mend some weaknesses he had perceived in his driving at this circuit.
I confess a certain weakness still for that savory egg-cloaked sole.
Though he showed generosity to Mephibosheth, the sole surviving son of the house of Saul, he showed his weakness for the charms of, the wife of Uriah, one of his generals.
