Regardless of the race of the author, painting broad strokes that focus on whole communities as the sole nucleus of a problem seems particularly naïve for a venue that claims to be iconic and experienced.
They are, with the minor exception of the nearby vestibular nuclei, the sole sources of output from the cerebellum.
Since centrosome proteins accumulate at the nuclear surface in these differentiating cells [6] [8], we investigated whether nuclei represented the sole microtubule organizing centres and whether the residual "centrosomal elements" (i.e. centriole-containing clusters as described in [7]) had lost their original potential of microtubule nucleation.
With the sole exception of the dentate nucleus in older subjects, controlling for seizures or sudden unexplained death in epilepsy (SUDEP) in analyses did not affect the significance of the difference in cell soma volume between autistic and control subjects.
This nucleus, which is the sole source of noradrenaline in the PFC (Loughlin et al., 1982), receives inputs from both GABAergic and glutamatergic projection neurones, from the nucleus prepositus hypoglossi and nucleus paragigantocellularis respectively (Ennis and Aston-Jones, 1989; Aston-Jones et al., 1991).
DOI: http://dx.doi.org/10.7554/eLife.00736.003 The integrity of the laterodorsal tegmental nucleus is important, being the sole source of anterior thalamic cholinergic innervations and a major source of interpeduncular cholinergic inputs (Satoh and Fibiger, 1986; Sikes and Vogt, 1987).
It is, however, agreed that the lateral mammillary nucleus in both the monkey and rat brain is the sole source of the mammillary projections to the anterior dorsal thalamic nucleus (Shibata, 1992; Hopkins, 2005; Vann et al., 2007), with individual lateral mammillary neurons bifurcating to project both ipsilaterally and contralaterally to the anterior dorsal nucleus (Kuypers et al., 1980).
Alternatively, it may be overly simplistic to view either the nucleus or the cytoplasm as the sole site of toxicity.
The results allowed us to discard the notion that p14 is entering the nucleus, or is retained within, as the sole consequence of being part of a larger complex.
Here, we show that in the protist Trypanosoma brucei, two proteins are the sole forms of RNase P. They localize to the nucleus and the mitochondrion, respectively, and have RNase P activity each on their own.
