Sentence examples for sole mutation from inspiring English sources

Exon 18 mutations are extremely rare comprising of 4.1% of all EGFR mutations and the delE709_T710insD mutation accounts for only 0.16% of mutations when occurring as a sole mutation, however, the frequency can vary with the kit utilized for testing.

Mutations in both Lys53 and Lys90 to Ala N-PTBK53K900) reduced sulfatide binding by about 3-fold (Fig. 1C), similarly to a sole mutation at Lys53 (Fig. S1C).

Although we do have shown an association of this mutation with rectal cancer (manuscript in preparation), it is unlikely that this sole mutation is causative to oncogenesis, but it could contribute to enhance genetic instability, one of the major hallmark in cancer cells.

That it is the sole mutation among ST-1655 isolates probably reflects the recent, rapid expansion of this particular lineage.

E200K is unlikely to be the sole mutation that determines CJD onset, since there are some elderly individuals (age, up to 85 years) in this study.

The three other indeterminate sequence variants (p.Ala2704Val, p.Ser2935Phe p.His3559Pro) are the sole mutation with potential pathogenicity observed in the three individuals screened.

For the PGL group, 3/12 cases (25%) expressed TERT, including the sole mutation-positive tumor (Fig. 2; Supplementary Table S2).

Next, monoallelic lesions were analyzed, that is, samples with sole TP53 mutation (n=3), sole 17p deletion (n=4), sole ATM mutation (n=6) and sole 11q deletion (n=12).

Because MYD88 L265P has been reported as the sole MYD88 mutation in WM with the very high occurrence rates up to 100%, sensitive AS-PCR methods to detect this mutation, similar to the one we used in this study, have been developed to assist differential diagnosis of WM from other indolent lymphomas producing monoclonal IgM.

First, E200K may be the sole pathogenic mutation associated with CJD in these individuals.

Firstly, the residue K138 (the only sole point mutation that reduced NF449 sensitivity) points away from the proposed ATP-binding site in the P2X1 receptor homology model.