Sentence examples for sole iron from inspiring English sources

In the original study demonstrating heme-regulated expression of PrrH, a knockout of the entire prrF locus led to a significant decrease in growth on heme or hemoglobin as a sole iron source, suggesting a role for PrrH-repressed mRNAs in heme utilization [27].

In fact, non-toxic concentrations of hemin (2.5 μM) as sole iron source allowed comparable growth rates and cell yields as the same concentration of FeSO4 (Frunzke et al. 2011).

A Δ hrrA mutant of C. glutamicum showed a strong growth defect on agar plates containing hemin as sole iron source, suggesting that also the C. glutamicum HrrSA system plays a role in heme metabolism.

Transcriptome studies revealed that all of the aforementioned genes related to heme metabolism and a few additional ones showed increased expression levels when heme was used as sole iron source (Frunzke et al. 2011).

Furthermore, the RR HrrA was shown to bind to the cgtS8-hrtB intergenic region and expression of cgtSR8 and hrtBA was increased two- and ten-fold, respectively, in the Δ hrrA mutant during growth with heme as sole iron source.

Hepcidin is synthesised in the liver and inhibits active transmembrane export of iron by blocking ferroportin, the sole iron-transporter responsible for iron efflux from enterocytes and macrophages (Nemeth et al, 2004).

Hepcidin acts by binding to ferroportin, which is the sole known iron exporter [ 13].

Hepcidin acts through binding to ferroportin, the sole known iron exporter [ 8].

It binds to and initiates degradation of ferroportin-1 (FPN-1), the sole elemental iron exporter in vertebrates [ 35– 35].

The bacterium is able to use porcine transferrin as well as haem proteins as sole sources of iron. A. pleuropneumoniae genes known to be involved in iron uptake are the porcine transferrin specific outer membrane (OM) proteins, tbpA and tbpB, the co-transcribed tonB-exbB exbD complex [ 21- 23], and the second tonB system, designated exbB2- exbD2- tonB2 [ 24].

Hepcidin inhibits the function of ferroportin, the sole known mammalian iron export protein, expressed highly on duodenal enterocytes and iron-recycling macrophages.