Also, Akt1 appears to be the sole down-regulated protein in the pathway during involution, implying a critical regulatory role during this developmental stage.
In the common sole, down-regulation of IGFBP-1 mRNA and increased expression of IGFI mRNA were observed during metamorphosis, followed by an inversion of this trend after metamorphosis.
Set the shoes, soles down, in a well-ventilated area of the house.
Check faucets, drawer handles all down and flat against drawer, shoes in closet all sole-down, bottom sheet tightly tucked around mattress corners, blanket covering feet.
Following in the footsteps of community associations and historic districts, which have always curtailed the liberties of homeowners in exchange for maintaining property values, many boards are exerting an iron-fisted authority over issues that were once owners' sole domain, down to the knocker on the front door.
The fact that their soles wear down so fast?
Finally one of his boot soles wore down to a wide hole and the freezing forest floor and wet riverbank became impossible, and Nick joined me for good in the greenhouse.
Although RNAi phenotypes are generally assumed to be due to the sole knock-down of the targeted gene, they can also be due to multi-gene silencing.
She leads with her toes and slaps her soles down flat -- which is how she has walked ever since she jumped from a five-story window when she was 26.
And they're made for keeps: The sole and upper are stitched to a welt (a hand-cut piece of leather) in a patented process that allows for easy re-soling down the road.
"Now he's the sole guy down there at the particular moment," Collins said, "and we've got to be careful we don't overdo it with him".
