111 In a phase I study in advanced or refractory NHL, pixantrone was tolerable at doses associated with antitumor activity, with grade 4 neutropenia as the sole dose-limiting toxicity.
Our studies are the first direct demonstration that radiation-triggered cell death is susceptible to the energy of the individual photons from an electromagnetic radiation source, such as X-ray, rather than the sole total dose absorbed by the system.
However, a retrospective review of 60 phase I trials of targeted agents reported mainly between 1999 and 2002 revealed that the majority of studies had used toxicity as the sole determinant for dose selection in phase II studies.
However, the effects of GIP when administered as a sole agent at doses that are pharmacological in this group are unknown.
Treatment alone with GSK343 showed no significant reduction in cell viability up to 15 μM, while UNC0638 sole treatment caused a dose dependant reduction in cell viability, with a calculated IC50 of 9 μM.
Three patients (CRC15, 22, 24) received only three doses of vaccine due to early disease progression, one patient (CRC7) completed all four doses as sole therapy for an early local recurrence of a pelvic primary tumour but progressed again shortly afterwards.
Pantoprazole, an inhibitor of the enzyme primarily responsible for voriconazole metabolism (CYP2C19), was continued at the same dose during both sampling episodes, and thus was unlikely to be the sole contributor to the changes in voriconazole exposure.
These trials have focused on small solute clearances as sole measures of the RRT dose [ 16].
Among MA dUCBT recipients, CD3+ cell dose remained the sole independent predictor of the predominant unit (OR 4.4, 95%CI, 1.8 10.6, p<0.01) with a larger dose more likely predominating.
