We therefore conclude that the constitutional MMR malfunction in our PMS2−/− Patient 1 was not the sole DNA repair defect responsible for the supermutator phenotype observed in her rectal cancer.
Interfering ventricle-specific transcription factors and/or their effectors can cause sole ventricle developmental defects [9].
A reduction in crystalline cellulose may not be the sole contributor to the defect in xylem integrity; a reduction in lignin might also be a contributing factor.
Further, whereas the genetic depletion of any of the three tested hormones led to timing defects, for genetically increased levels of hormones, only GA led to noted physiological timing defects; the sole increase of ABA and BR did not lead to dramatically modified responses.
However qualitatively, the distinction that appears in cascade simulations, between direct impact amorphization and sole creation of point defects is reproduced by thermal spikes calculations.
However, in our opinion, it is very unlikely that an erythrocyte membrane defect was the sole cause of the increased OF in the dogs of our study, because all dogs with an increased OF had additional criteria for immune-mediated red cell destruction or had pronounced hyperlipidemia.
Furthermore, podocytes that express Myo1e(as59P) as the sole source of Myo1e exhibit defects in actin assembly at cell-cell junctions (Bi et al., 2013).
This observation also rules out gross sensory defects as the sole cause of dysfunction, as they would prevent males from finding and identifying females.
