How this combination compares to tamoxifen alone is currently being investigated by the SOFT trial (NCT00917969).
She is currently under house arrest, an unusually soft pre-trial treatment for the Russian legal practices.
As the only chancellor who has ever managed two different coalitions, she is non-ideological and has been floating soft-leftish trial balloons all year, from a minimum wage to higher pensions for mothers and restraints on rent increases.A government of CDU and SPD is in fact what 52% of German voters say they want.
The SOFT and TEXT trials, whose accrual is now complete, should help to define optimal endocrine therapy.
So one can state, in general, that using unselected populations in soft tissue sarcoma trials increases the number of patients recruited, but at the same time diminishes the chance of reaching a statistically significant clinical benefit.
(By contrast, the Republicans got $2,800 in soft money from trial lawyers, Common Cause reported, of $57.8 million in soft dollars over all).
The frequency of use of GnRH analogues in community practice is unknown, and their role is being addressed in the multi-national intergroup Suppression of Ovarian Function Trial (SOFT).
The Suppression of Ovarian Function Trial (SOFT: IBCSG 24-02) is designed to determine the role of OFS and the role of aromatase inhibitors for women who remain premenopausal after surgery alone or after completion of adjuvant and/or neoadjuvant chemotherapy.
The Suppression of Ovarian Function Trial (SOFT) compares the efficacy of tamoxifen versus OS plus tamoxifen versus OS plus exemestane for five years in premenopausal women with HR-positive breast cancer; this trial includes women who have received adjuvant chemotherapy and remain premenopausal thereafter.
All the compounds that have been trialed in soft tissue sarcoma or that are in clinical trial at present are summarized in Table 2. Bevacizumab is the only anti-VEGF monoclonal antibody that has a proven activity against some forms of STS, especially in combination with other chemotherapic agents such as doxorubicin.
In 2003 the International Breast Cancer Study Group (IBCSG) initiated the TEXT and SOFT randomized phase III trials to answer two questions concerning adjuvant treatment for premenopausal women with endocrine-responsive early breast cancer: 1-What is the role of aromatase inhibitors (AI) for women treated with ovarian function suppression (OFS)?
