Exact(4)
The paper describes the techniques adopted to acquire and create the digital model of the residual limb, the procedure to generate the socket model, the strategy developed for the functional simulation of the socket-stump interaction and, finally, the realization of the physical prototype.
Based on these findings, the "two-pronged plug two-holed socket" model has been proposed, which postulates that binding of phosphopeptides to the Src SH2 domain is determined by phosphotyrosine and the hydrophobic residue at position pY+3.
However, binding studies of conformationally constrained peptide analogs of pYEEI show that they have higher binding affinities than the unconstrained pYEEI [10], [11], suggesting that the "two-pronged plug two-holed socket" model may be an oversimplification and that any binding model must take into account the inherent flexibility of short peptides.
While in good agreement with the crystallographic and NMR studies of high-affinity phosphopeptide-SH2 domain complexes, the results suggest that the structural basis for phopsphopeptide- Src SH2 interactions is more complex than the "two-pronged plug two-hole socket" model.
Similar(56)
The artificial cervical disc was simplified and designed as a ball-on-socket model with the material configuration of CPE/TC4, XPE/TC4 and PEEK/TC4, respectively.
The torsional fretting wear behavior of the ball-on-socket model was tested at different angular displacements under 25% bovine serum lubrication with an axial force of 100 N to obtain more realistic results with that in vivo.
The frictional kinetic behavior, wear type, damage region and damage mechanism for the ball-on-socket model revealed significant differences with those of a ball-on-flat contact while showing better consistency with that of in vitro cervical prosthesis simulations according to the literature.
We used three brands of PDAs in the project: Hewlett- Packard iPAQ 210 Series (Palo Alto, CA), Socket SoMo Model 650-M (Newark, CA), and Dell Axims (×50 and ×51) (Round Rock, TX).
Inspired by the spontaneous nature of his kids, this roundup of his recent personal projects includes the Snoutlets (pigs with snouts made from electric sockets), a model of Stonehedge built from Rice Krispies, a gummy bearskin rug, and the Twinkie Circuitry, above, which juxtaposes the soft, creamy texture of a Twinkie with its rigid mechanical interior.
The malleus-periotic joint (approximating a ball and socket) was modeled as fused.
Harryhausen used a standard technique, pioneered, if not invented, by Willis O'Brien, the guy who made the ape in "King Kong": articulated "ball-and-socket" miniature models, animated through an achingly slow and painstaking frame-by-frame process, with the intricately choreographed result then laid in alongside live-action actors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com