Social defects are also common to many mutant mouse models of synaptic dysfunction or schizophrenia susceptibility genes (30, 47, 70).
However, it is not clear how mutations in the same gene can have divergent consequences, ranging from severe ID to prominent social defects with preserved intellectual function.
It is a common cause of death and disability in industrialized countries for both adults and children, with sequels ranging from physical disabilities to long-term behavioural, cognitive, psychological, and social defects [ 4].
In an analysis of gene phenotype associations (Meehan et al., 2011), autism-related genes were found to be associated with a cluster of phenotypes that included social defects, abnormal motor behavior, and cerebellar foliation.
We also demonstrated that reexpressing the β2-subunit of the nAChRs specifically into the PFC of β 2−/− mice was sufficient to restore normal social patterns in these animals, thus showing that β 2−/− social defects were not due to gross compensatory mechanisms (24, 34, 35).
An abnormality in these brain regions may lead to other social cognitive defects.
Many political observers believe he is acting to secure his legacy as an old-fashioned Kentucky liberal representing a tradition that has been in retreat for a generation, since social conservatives began defecting to the Republican Party.
A fixture on Southampton's fashion and social scene before defecting to its sister city, Palm Beach, Fla., Mr. Stolman used to score club T-shirts from the Southampton Bathing Corporation, known as the Beach Club, and also from the Meadow Club and the Southampton Bath & Tennis Club, or the B&T, at local thrift shops.
Some say this lack of social skills is a defect, but it can also be a hidden advantage.
