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Survival of dentate gyrus cells that either proliferated prior to the stress period or 24 h after the last defeat was not affected by the social defeats.
Because social defeats lead to the activation of the serotonergic system [17], [44], the changes in the Snca mRNA levels in the losers' raphe nuclei lend support to the involvement of a-Syn in the consequence of chronic negative emotions.
Daily social defeats are accompanied by activation of serotonergic system as shown by changes of serotonin and 5-hydroxyindoleacetic acid levels in different brain areas of the losers [10], [17] and enhanced expression of Sert and MaoA genes in the raphe nuclei of the midbrain [18].
There was a significant decrease in cell proliferation in mice that received 10 social defeats [ 139].
Similar(56)
That would be an admission of social defeat.
To spend an evening by oneself is to admit social defeat à la Bridget Jones.
The impact of the SNS on the immune modulation of social defeat has not been examined.
Chronic social defeat stress (CSDS) produces persistent behavioral adaptations in mice.
This design resulted in only a very brief social defeat, yet when comparing defeated animals with no-defeat controls, a significant increase in social avoidance was still observed.
Secreted by stress in models of repeated social defeat, increased plasma IL-6 levels is a hallmark of the physiologic response to a stressor.
This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psychotic symptoms and reduced social functioning.
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