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Dr. Evans believes that resveratrol acts on so many pathways in the cell, particularly at high doses, that it is hard to know how it is achieving any given effect, whereas the role of Aicar and GW1516 is well defined.
So many pathways remain to be explore in order to determine CD40/CD40L cellular mechanism.
Clipper and DEgraph declare so many pathways as significantly activated because they detect sub-graphs, which are portions of signaling circuits of dubious biological meaning.
Note that KEGG incorporates information for all species available, so many pathways may include enzymes that are not relevant leading to misleading interpretations of pathways that might appear absent or present in the species.
There are so many pathways involved in metastatic process and one of the most important is the EMT (epithelial-mesenchymal transition) which is associated with a gain of stem cell-like behaviour.
Whatever the mechanism, the presence of a pathway that maintains the homoeostasis of CtBP protein abundance in proliferating cells is perhaps not surprising, given the critical role of these proteins in so many pathways that define the cellular phenotype.
Similar(52)
"So many new pathways for lead have emerged," said Dr. David C. Bellinger, an associate professor in neurology at Harvard Medical School.
I think we're just beginning to appreciate the fact that there are so many parallel pathways that can lead to prematurity, and as we try to stop one, another one picks up the slack.
They have to be neutralised and degraded, and there are only so many biochemical pathways capable of doing this, most of which are found in the liver.
This gap in our knowledge motivated us to focus on the effects of DR on the metabolome, which includes the building blocks of so many functional pathways in an organism.
These many parts are controlled by numerous pelvic muscles and so many firing nerve pathways that they make the German autobahn look like a pedestrian promenade.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com