These genes which have not been detected in any adult tissues might represent pseudogenes, may be expressed in earlier stages (which are not the focus of this study), or could be expressed in adults at so low levels that were not detected under the conditions employed in this study.
It should be noted that clathrin-independent endocytosis can occur even when the cholesterol level in the membrane has been reduced to so low levels that caveolae are gone and clathrin-coated membrane areas are flat.
This can be so low-level that you might not think of it as activity at all.
Across the country, they are signing up to be Republican precinct leaders, a position so low-level that it often remains vacant, but which comes with the ability to vote for the party executives who endorse candidates, approve platforms and decide where the party spends money.
The activation of CaMKII is highly cooperative (Gaertner et al., 2004; Rosenberg et al., 2005), so low levels of Ca2+/CaM that are insufficient for autophosphorylation of an unactivated holoenzyme may be sufficient for binding the target subunit and enhancing its autophosphorylation in holoenzymes that contain some activated subunits through exchange.
Over the decades prior to it the Fed rooted inflation expectations so firmly at low levels that households ceased to think about broad price and wage shifts as economically meaningful.
The apparent challenge of the game was then at so low a level that Arsenal could hardly bring themselves to rise above the ordinary.
But in practice, Europe has focused on human rights and democracy issues, so low-level attendance in Phnom Penh suggests that European governments prefer to play to domestic galleries than to bring real weight to bear on the Asian issues.
Orthodox contract remedies merely price breach; and they set prices so low (at levels that enable breaching promisors to profit from their wrongs) as to encourage breaches of the very obligations that contract law purports to establish.
Back then they recalled there was only one very small cay that was so low above sea level that it was almost submerged by the high tide.
While chick clock gene orthologs continue to cycle in culture, they do so at low levels, suggesting that significant signal amplification and/or posttranscriptional regulation must occur if these genes are driving the larger amplitude rhythms seen in the physiological output of the cells, as well as the expression of other more highly rhythmic genes.
