Drugs which target cancer cell invasion and metastasis have proven difficult to develop, so an improved understanding of the detailed mechanism of chemotaxis may enable the prioritisation of better drug targets, better drugs, appropriate patient selection and smarter early clinical study design [10].
Mutations of the gene that codes for human p97 can cause a number of diseases, including Paget's disease of the bone and frontotemporal dementia, so an improved understanding of ribosome-associated degradation could provide new insights into these diseases.
Finally, given the long latency period in most cancers, early detection to cancer is key so an improved understanding of the biology within originating tissues (during the latency period) would be very helpful.
As discussed by, for example, Nguyen et al., the majority of PTEN in a cell is not bound to the membrane, so an improved understanding of the mechanism of PTEN bilayer interaction offers a longer term prospect of developing activators of PTEN function for therapeutic applications.
The only way to develop an effective process is to study it, applying the same rigour to the research process that has so successfully led to our improved understanding in biochemical and physiological systems, culminating in the medical successes that we enjoy today.
In that particular study, student performance on exams was not analyzed, so it is not clear whether this improved understanding was reflected in an improved performance on exams.
The technique of looking for such blips in starlight, the astronomers said, could point the way to the discovery of many more extrasolar planets, so-called exoplanets, and an improved understanding of their properties.
However, robust oligodendrocyte production from hNSC has not been reported so far, indicating the need for improved understanding of the molecular and environmental signals controlling hNSC progression through the oligodendroglial lineage.
The efficiency of LEDs based on conjugated polymers have been enhanced by synthetic design, based on improved understanding of defect formation and its prevention, so that they are now commercially viable.
An improved understanding of the occurrence of this process is essential so as to be able to design reliable disaster risk reduction strategies, even more so in view of ongoing climate change and scenarios of future evolutions.
