So far, large-scale approaches to identify TSP-1 ligands have been rarely used, but many interactions have been identified in small-scale studies in defined biological systems.
So far large-scale production of 3-HP has been mainly through petroleum-based chemical processes, whose sustainability and environmental issues have attracted widespread attention.
Geranylgeranylation can be performed in vitro using recombinant GGTase-II but so far large-scale production of the enzyme was challenging.
So far, large-scale evidence on the economic costs of meritless class action litigation is surprisingly scarce, and our results indicate that such costs may be substantially higher than commonly thought.
The trouble is that, so far, large-scale insect-farming has proved technologically and financially impossible.
So far, large-scale analysis of CNVs has been limited to copy number estimation in diploid genomes.
So far, large-scale T-cell repertoire analysis has been limited to interrogation of a single TCR subunit per sequencing run.
So far, large-scale gene sequencing studies have demonstrated that, with the exception of VHL, there are no genes that are mutated very frequently, but a significant number of genes do show frequent tumor-specific methylation.
So far, large-scale genome-wide analyses of the DNA context of point mutational events have relied on either disease-causing mutations or SNP data from NCBI's dbSNP [ 25].
So far, large-scale studies of emotion in lexical processing have not addressed the question of whether the valence effect is being driven by a specific, limited set of words: those referring explicitly to emotion, or whether it generalises to all valenced words.
