Prolonged exposure to the non-NO releasing congener of SNAP (NAP; 3 mM) elicited no change in TRPA1 and TRPV1 channel activity for at least twice the average latency to observe SNAP effects (Fig. 3B; p>0.2 for TRPA1 and p>0.7 for TRPV1).
To support the idea that SNAP effects on Ca2+ oscillations were mediated by PKG, we studied the effect of the potent PKG activator cGMP analogue 8pCPT-cGMP on the AVP induced Ca2+ oscillations in myocytes and pericytes of ureteric microvessels.
On each occasion, he would wear his polished helmet, full dress uniform, gleaming riding boots, and carry a riding crop to snap for effect.
Not only do they slide securely and precisely along their grooves, but they make a nice, tactile little click at the end — accompanied not only by a snapping sound effect from the tablet — but a subtle on-screen effect indicates each one is locked in place.
Then the unions demanded a "snap back" to take effect in 2000, restoring them to pre-ownership levels.
Elbowing into war zones his heroes snap harrowing photographs whose effect, if any, on the international conversation is never mentioned.
Before you get the wrong end of the stick and snap up a satin effect blazer and tie, remember that the only way to make work-wear sexy while it still being remotely appropriate, is to hint at the twisted nymphomaniac that lies beneath.
Back on the balcony, heads begin to flutter and snap awake as the effects of the K slowly start to wear off.
Now scientists at M.I.T.'s Media Lab are using an ultrafast imaging system to capture light itself as it passes through liquids and objects, in effect snapping a picture in less than two-trillionths of a second.
Pop-music snobs usually don't rank Dupri as high as they do auteurs like Dr. Dre and the Neptunes, and they fail to recognize his knack for isolating what is best about a trend and exaggerating it to wonderful effect; if Atlanta snap music is spare and weird, he'll make it positively barren and dissonant.
