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Whether a selected marker fell within 500 kb of a GIANT-identified marker was determined by consulting the Broad Institute's SNAP database [ 40].
We utilized the 'proxy search' tool provided by the SNAP database to obtain SNPs having high LD with the predicted MRESS SNPs.
All SNPs in high LD (r ≥ 0.8) with the cis-eQTL were obtained from SNAP database (http://www.broadinstitute.org/mpg/snap) [ 86] using CEU as the reference.
We based our proxy criterion on basepair distance rather than LD, as we found the correlations between SNPs in our dataset to be larger in magnitude than those recorded in the SNAP database.
For the remaining SNPs (n = 66), we looked for the SNPs that are highly correlated (r = 1) using the Caucasian (CEU) 1000 genomes Pilot 1 data in the SNAP database (http://www.broadinstitute.org/mpg/snap/ldsearch.php) [ 11]; we reasoned that these "proxy" SNPs can be used to investigate the associations of these SNPs in our cohort as they have identical genotype distributions (Additional File-1).
All SNPs in linkage disequilibrium (LD) (r2 ≥ 0.5) with the 49 GWAS PCa SNPs (reached genome-wide significance level with a p-value ≤ 10-5) were obtained from SNAP database (http://www.broadinstitute.org/mpg/snap/ldsearchpw.php; proxy search; CEU genotype; 1000 Genomes Pilot 1 data set) [ 75].
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To perform a replication study of the initial findings, the LD pattern of the 10 SNPs, which showed significance in the Discovery sample, was investigated in the SNAP Proxy database (http://www.broadinstitute.org/mpg/snap/ldsearch.php).org/mpg/snap/ldsearch.php
The cameras snap pictures of faces and compare them with 30,000 images in a database that includes runaways and wanted criminals.
Good, snap a picture of yourself and upload it to Costume DB, a no-frills database for costumes.
For that to happen, a massive database of faceprints need only be on the market for advertisers to snap up or connected to offline recognition systems — and Facebook happens to own such a collection.
Step inside her Gifotomat, snap a shot, and using an algorithm it selects the closest visual match from a huge database of paintings.
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