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First, the volume is resampled in the z direction with 1 mm slice thickness using B-spline interpolation to reduce partial volume effects and produce smoother segmentation results.
The algorithm might also be further improved to have a smoother segmentation over the cardiac cycle by using more than two time frames in the optimization of parameters and hence possibly get a higher weight on the time dependent parameter.
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Note that this gives significantly smoother segmentations than running the MRF directly on the patch-level output.
Based on a correlated random-effect model for the unobserved patterns, MPSS takes a robust smooth segmentation approach to identify whether a segment is a true CNA [ 13].
This allows a smooth segmentation of the image.
A clear contrast between lateral ventricle and hippocampus offers a smooth segmentation border.
The first term is the prior term which is the classic boundary length term [25] for smooth segmentation boundaries.
A preprocessing pipeline was designed to reduce imaging noise, smooth segmentation results and construct an anatomically correct oral model from patient-specific data.
The contour initialization strategy allowed the employment of many types of tongue priors, such as color, shape, and symmetry, to obtain a satisfactory initial contour, and the GVF snake was able to obtain a local optimal and smooth segmentation results.
Nonetheless, the proper assessment of copy numbers is not a trivial task and several computational algorithms have been developed for normalization, smoothing, segmentation and calling [ 5- 9].
Several methods have been suggested for the extraction of CNAs based on different principles, such as filtering (or smoothing), segmentation, breakpoint-detection and calling [ 9– 16], taking into account one sample at a time [ 17].
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