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Already by 1981, Main had theorized that a conflict between attachment and anger would also be capable of disrupting the smooth expression of the attachment system.
Main observed that the conflict between anger and attachment could flood out and interrupt the smooth expression of the attachment system, such that the infant would primarily be focused on expressing rage rather than oriented by their attachment system toward what proximity would be available from the caregiver.
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In order to construct the network of transcriptional regulators (i.e., TFs and chromatin regulators) that coordinate the N starvation response, we computed the distances between temporally ordered, smoothed expression profiles of the transcriptional regulators (TRs) and the transcriptionally co-regulated modules.
Alterations to caveolae in smooth muscle cells will also impact on cell signalling and recent studies of idiopathic pulmonary arterial hypertension in humans have concluded that increased smooth muscle expression of caveolin-1 contributes to the pathophysiology of the disease through increased capacitative calcium entry [ 38].
These cells can be distinguished from basal cells in stratified squamous epithelium because they exhibit many features of smooth muscle cells, including expression of smooth muscle actin (SMA), myosin [ 4] and neutral endopeptidase (CD10) [ 5] The term 'myoepithelial' cell was coined to describe cells that express both epithelial characteristics and these contractile proteins.
With bioreactor cultivation, progenitor cells differentiated toward smooth muscle lineage characterized by the expression of smooth muscle (SM -specific markerSM -specificcle alpha actin (Smarkersin) and smooth muscle myosin healphahactinSM-α-actin
To determine whether the cardiovascular defects observed in the Wnt1cre; Ilk flox/flox mutants were caused by defective differentiation of NCCs into smooth muscle cells, we analyzed the expression of smooth muscle actin (αSMA), a broadly used marker of smooth muscle differentiation.
In the adult mammary gland, the smooth muscle marker expression of myoepithelial cells appears to be heterogeneous.
Furthermore, Shh-Cre driven conditional Ihh Shh mutant has a drastic reduction of gut mesenchyme and smooth muscles, and expression of an activated Smo (Smo-M2) drastically increases mesenchymal mass (Mao et al., 2010).
Interestingly, KCNJ3 (Kir3.1) and KCNJ6 (Kir3.2) transcripts [G protein-gated inwardly rectifying K+ channels, (GIRK)] were also detected in canine colonic smooth muscle and expression of both proteins was confirmed by immunohistochemistry (2).
In response to tissue injury and stimulation with growth factors (e.g., TGF- β), fibroblasts can adopt an activated phenotype resembling that of smooth muscle cells and characterized by the expression of smooth muscle actin (α-SMA).
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