In women with prolapse, vaginal smooth muscle content was most diminished in specimens from postmenopausal women with no estrogen replacement.
Percent corporal smooth muscle content, a traditional predictor of corporal veno-occlusive function, is invasive and clinically assessed by histomorphometric analyses of erectile tissue biopsies.
Objective: The purpose of this study was to compare the smooth muscle content of the anterior vaginal wall in normal women and women with pelvic organ prolapse.
Compared with the inner and outer layers of the MP which were expanded 2.1 ± 0.2- and 1.4 ± 0.1-fold, respectively, the MM was expanded 22.1 ± 3.6-fold, reflecting the combined effects of architectural disarray, an 11.6 ± 1.4-fold increase smooth muscle content, and elaboration of pericellular type V collagen.
In addition, computerized measurements of CD68 and alpha-actin were performed to assess macrophage and smooth muscle content respectively.
However, plaque stability also depends on collagen and smooth muscle content, which were both not modulated in our study.
L-4F plus pravastatin-treated mice also showed increased α-actin smooth muscle content in aortic lesions compared to controls (7.8 ± 0.5% vs. 4.9 ± 2.3%; P = 0.04).
Heart and tongue also showed significant similarities, with uterus and prostate both scoring positively, probably linked to the relatively high smooth muscle content.
Additionally important, Youssif et al. found that VEGF enhanced neovascularity and increased smooth muscle content especially in early periods after BAM grafting [ 23].
In rabbits, testosterone deficiency induced by castration reduced trabecular smooth muscle content, and this reduction was restored by testosterone treatment [ 30].
