In the SMART study, involving 208 patients with active RA in whom anti-TNF agents had failed or were contraindicated, serum IgG > 12.66 gm/liter (upper limit of normal) arose as independent predictors of response to rituximab with an OR of 2.11 and synergistic with RF and/or ACPA [ 120], confirming that anti-CD20 treatments may be particularly indicated in the B cell-driven subtype of RA.
Although in the larger SMART study CXCL13 was not associated with EULAR response at week 24, another chemokine involved in B-cell migration, that is, CCL19, turned out to be predictive in a multivariable model not including autoantibodies [ 59].
The SMART study is an ongoing prospective single-centre cohort study in patients with manifest arterial disease or cardiovascular risk factors [ 20].
Pick a smart study partner who will keep you focused.
Data was collected from each participant including; gender, age, previous anaesthetic experience (years) and level of training, number of estimated intubations with the Macintosh blade, Glidescope®, flexible fibreoptic bronchoscope and their familiarity with smart phones.The study design was a randomized crossover design.
"All of the smartest people I studied with were in the United Kingdom, the United States and Australia," he says.
So you think Cory was smart to study Spanish – to connect with voters in those heavily Hispanic areas?
The SMART-1 study (n=327 patients with moderate to severe urinary symptoms, IPSS ≥12) was initiated to investigate speed of symptom relief with tamsulosin combined with dutasteride, then maintenance of effect following withdrawal of the alfa blocker after 6 months (Barkin et al. 2003).
Aldraihem and Khdeir (2000) studied smart beams with extension and thickness-shear piezoelectric actuators.
Her smart daughter, Beneatha, is studying with hopes of being a doctor, and her dissatisfied son Walter (Ashley Zhangazha) is a chauffeur with dreams of running his own business.
