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I've read smart analyses from such fans, who are typically women, but other times they operate less like viewers than ombudsmen.
In the build up to the keynote, a bunch of people did some very smart analyses of Apple's previous product launch keynotes and exactly how Steve Jobs set up the big reveal.
Finally, we manually refined the search results based on the Pfam (PF05042) and SMART analyses to further reduce hits with partially conserved functional domains and other false positives.
The presence of AP2 domains in the mulberry sequences identified in this way was determined by (http://smart.embl-heidelberg.de/) (SMART) analyses (Letunic et al. 2012).
MotifScan, InterProScan, SMART analyses indicated a two-domain structure with the C-terminal peptidase C1 domain [187 403 Aars, PF00112 and SM00645] and N-terminal cathepsin propeptide inhibitor domain I29 [99–155 Aars, PF08246 and SM00848].
This search produced 34 new protein matches, 23 of which (68%) were present among the 62 sequences detected by the HMM predictions but not confirmed by CDD or SMART analyses, plus another 11 that were completely novel.
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Together, our KC-SMART and comparative-KC-SMART analyses highlight important genotypic similarities between mouse and human cognate cancers.
In Simple Modular Architecture Research Tool (SMART) homology analyses, EmIR2 displayed a domain structure typical of insulin receptor tyrosine kinases, with a predicted signal peptide, a LBD composed of two receptor L domains separated by a furin domain, three fibronectin 3 domains, a transmembrane domain and an intracellular tyrosine kinase domain (TKD).
Using thousands of data points — concepts, structure, difficulty level, media format — and data on how the person uses it, it's like having a super smart teacher analyse everything you try to learn and suggest ways to make the process easier.
On the basis of reports suggesting frequencies of methylation greater than 20% for both DAPK1 and RASSF1A [ 8, 9, 68], sensitive-melting analysis after real time-methylation specific PCR (SMART-MSP) analyses were used to confirm a subset of the MS-HRM findings [ 97].
Finally, we manually checked the extracted proteins by SMART and Pfam analyses to avoid false positive hits that commonly arise during large-scale automated analyses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com