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Sensitivity analyses included application of continuity correction in trials of zero events 13 and exclusion of the smallest trial, the largest trial, and trials financed by industry.
The continuous outcome meta-analyses were based on a median of five trials (Q1-Q3: 3–9) with a median ratio between the largest and the smallest trial of 5 (Q1-Q3: 3–10).
The size of RCTs ranged from 33 recipients in the smallest trial to 1575 in the largest multi-site trial, yielding a total of 6255 recipients overall (Table 1).
Ratio >5, < = 5 studies: a selection of these meta-analyses based on at most five studies, where the ratio of the largest vs. the smallest trial size was > 5. DL: DerSimonian & Laird meta-analysis method.
The 434 dichotomous meta-analyses were based on a median of six trials (Q1-Q3: 4–10) with a median ratio between the largest and the smallest trial of 6 (Q1-Q3: 3–16).
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We've already had a small-scale trial.
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So far, it has just had some small trial orders.
Aguilar led me to a small trial plot.
In 2010, Oxitec began a smaller trial in Malaysia.
It was also a small trial, involving only 103 patients.
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