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In the smallest studies, the chance of finding a low EPP rate together with no mutant bands could be much enhanced.
After excluding the three smallest studies, the difference between the pooled odds ratio for these two categories decreased and was not statistically significant (3.67, 95% CI: 2.58 5.22, vs. 2.52, 95% CI: 1.98 3.19, table 2).
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In small studies, the devices successfully detected potentially malignant lesions that experienced specialists missed with the naked eye.
In March, the RAND Corporation issued an analysis combining the results of the many small studies; the analysis found evidence that ephedra works for weight loss in the short term, but can produce numerous cardiac side effects.
32– 34 In smaller studies, the association between sleep duration and diabetes is more variable.
In several small studies, the dopamine agonist cabergoline normalized urinary free cortisol in some patients.
However, in some smaller studies, the presence of comorbidity may have contributed to early referral.
In two smaller studies, the reported sensitivity was only 58% [ 11] and 69% [ 13].
The meta-analysis has been criticised for including many small studies, the oldest ones dating back to 1981.
Even for a small study, the MRI costs can run into the tens of thousands of pounds.
And there is one small study, the only one of its kind, that suggests that a placebo prescribed openly could win over some patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com