In order to find the smallest structural unit, able to bind nucleotides, and its coupling module, the hinge region, three truncated domains of NBD94 have been generated, termed NBD94444 547, NBD94566 663 and NBD94674 793, respectively.
The instrumented indentation, offering a broad range of loading forces, was chosen for characterization of these coatings at various scales: from the smallest structural units up to the coating as a whole.
Recently, a novel approach protein peeling has been proposed to divide 3D peptide structures into small structural units, termed protein units (PUs) (Gelly, de Brevern, et al. 2006; Gelly and de Brevern 2011).
Since the beginning of the 1970s, extensive efforts have been made to decompose 3D protein structures into smaller structural units for a better resolution of biologically meaningful elements (Wetlaufer 1973; Wetlaufer and Ristow 1973; Rossman and Liljas 1974).
We developed novel nucleoside-based topoisomerase II selective inhibitors and showed that small structural units, such as catechols, are essential for DNA topoisomerase II inhibitory activity.
No tangible proof was found for the formation of a glycerol rich phase in TPS, the relaxation transition assigned to this phase was rather explained with the movement of smaller structural units of starch molecules.
A theoretical interpretation of the contrasting LCST behavior of both NIPAM-co-MI and NIPAM-co-MA was obtained by quantum mechanical (QM) modeling on small structural units of the polymers as well as molecular dynamic (MD) simulations at LCST and above the LCST on 50-unit oligomer model of the polymers.
This biphasic model of evolution incorporates the previously developed concepts of the emergence of protein folds by recombination of small structural units and origin of viruses and cells from a pre-cellular compartmentalized pool of recombining genetic elements.
A single cell is the smallest structural and functional unit of an organism.
The WWE domain of RNF146 specifically binds to iso-ADP-ribose (iso-ADPR), the smallest internal PAR structural unit containing the characteristic ribose ribose glycosidic bond formed during poly-ADP-ribosylation rather than mono (ADP-ribose), leading to ubiquitination of poly-ADP-ribosylated Axin [ 234].
EUs are small standardized structural units capable of aggregating with each other and gathering the key functions of a typical satellite within the size of a 6U cubesat.
