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Imputing data using regression-based methods necessarily biases efficacy estimates toward the null, so it is not surprising that the fourth model yielded the smallest efficacy estimate of 2.3 fewer carious surfaces, on average, per child.
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Large gaps remain between small-scale efficacy studies and large-scale interventions, demanding effective strategies to support the management and supervision of CHWs in order to ensure quality of implementation (21).
The success of this small-scale efficacy trial pointed to a larger trial to investigate if this intervention would also be effective and cost-effective in the 'real world'.
Study design and statistical analyses should consider time-varying factors, such as changes in weight and medications, which may independently impact study outcomes, especially in small-scale efficacy trials.
In the future, similar policy initiatives would be better served by preliminary evaluation in small-scale efficacy trials to better inform recommendations for cost-effective implementation of universal postnatal care services prior to significant investment.
A good many of them seemed to have been amateurish affairs in which home-made bombs of small efficacy were used, but a number were obviously much more serious.
In a real GPCR, both potency and efficacy effects of ΔΔΨ may function in combination, although the large potency effect is likely to overshadow the small efficacy effect.
Results in this small efficacy trial showed that the iACT participants had significantly higher gains in wellbeing (between group, d = 0.46), life satisfaction (d = 0.65), and mindfulness skills (d = 0.49).
At Pfizer, we're relying on small efficacy studies earlier in the development process to help us make decisions about a compound's fate sooner.
Industry sponsored studies had smaller efficacy estimates than non-industry sponsored studies (Table 1).
These are mostly small efficacy safety studies and have so far only reported on safety profile (Banu and Goss, 2004).
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