It should be noted, however, that because of the variable but small concentration for individual samples, the signal-to-noise ratio is high.
The rationale is that the standard deviation for the blank sample is roughly equivalent to the standard deviation for small concentration of analyte [ 27– 29].
This assumption is valid for small concentration of intracellular metabolites which is usually fulfilled but may deviate to a certain extent for highly concentrated metabolites, e.g., of the TCA cycle (Rehberg et al. 2014).
Indeed, if we look to the levels of HCH isomers and HCB, they are all below 400 ng/mL culture medium, which is the smallest concentration tested for individual compounds and at which no response was recorded for these organochlorines in the cell-based assay.
A small concentration of F− is essential for normal mineralization of bones and the formation of dental enamel.
A small EC50 value corresponds to high potency, i.e., only a small concentration of drug is required for EC50 bioactivity.
For detecting smaller concentration of proteins, the LOD was improved by further optimizing the assay conditions to be at par with that of the currently available commercial protein detection methods such as microplate-based ELISA and Luminex's xMAP technology.
The theoretical calculation also indicates that indium is likely to replace lead during the doping process for the smaller concentration of indium (<3 at%) which complements the results obtained from LIBS and XRD analyses.
In other words, a double amount of TF produced after genomic shrinking, for a smaller concentration of non-specific binding sites, leads to a non-linear increase in the effective TF concentration and thus in the concentration of TF-sDNA complexes.
MBC is the smaller concentration of the drug necessary for elimination of 99.9% of the microorganisms tested.
InterOM pores are observed only in small concentrations for diameters of 80 2000 nm.
