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The approach will likely lead to product labeling that designates a drug for smaller patient populations.
Erbitux is approved for colon cancer only after other drugs have stopped working, a smaller patient population.
This may be attributed to the smaller patient number in the present analysis.
[9] with respect to smaller patient groups (186, 120, and 221 patients).
All such studies have also been performed in much smaller patient cohorts than in the present investigation.
As the targeted exon is relevant to specific subpopulations of patients with DMD, a number of AONs targeting increasingly smaller patient populations are required.
Due to smaller patient numbers in common clinical trials patients with rare diseases are subject to a higher risk for imprecise results.
Patellofemoral resurfacing had a significantly lower score than the two other types of arthroplasty, which can be explained by a significantly younger and smaller patient group.
Ore et al., on the other hand, reported inter-observer agreement of 91% based on two observers in a smaller patient sample [15].
"And smaller biotech companies are very interested in generating biomarkers, working on proof of concept, and testing in smaller patient populations".
Key advantages of using IVUS-based surrogate end points versus clinical outcome include smaller patient numbers and substantially shorter trial durations; this reduces costs and may expedite the development and testing of new drugs.
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