Exact(8)
Specifically, if pathway pair A and pathway pair B shared more than 50% synthetic lethal interaction edges, the smaller pathway pair was removed.
For summary statistics and function enrichment analysis of the identified pathways, if pathway A and B shared more than 50% member genes, the smaller pathway was removed.
Furthermore, all of the targets of recurrently deregulated miRNAs were tested against a smaller pathway set: all 29 pathways catalogued under the hierarchical designation of 'pathways in cancer' in the KEGG database using GSEA.
Like a puzzle, the discovery of each smaller pathway contributed a piece to the final solution.
However, we observe that as K decreases, the distribution shifts towards smaller pathway lengths.
Regarding the pathway length distribution of the EMs, the results show that there can be a bias towards smaller pathway lengths for low values of K.
Similar(52)
Both definitions make sense because the first definition focuses on the functional redundancy of the two smaller pathways while the second definition focuses on the fact that all these genes are involved in one specific cellular function.
This can be explained by the fact that some of the smaller pathways are subsets of larger pathways.
The dynamics of some of these smaller pathways, like the MAPK signaling and Ras signaling pathways, have been described under various cellular conditions [ 7- 9].
The second part gives smaller pathways a fitness advantage, the extent of which is controlled by the parameter c (for the reported results c was 0.001).
MetaPathwayHunter [ 23] developed by Pinter et al. enables fast queries for smaller pathways but is limited to those that take the form of a tree (i.e. a subnetwork with no loops).
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