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The slow component had a smaller effect and half-distances from 30 to 150 m.
While additional loci may be nominated, these assignments are likely to be of smaller effect and will require independent validation.
Gene-based methods, which are ideal for pathway-based approaches (Liu et al. 2010), permit the aggregation of SNPs of smaller effect and test the gene as a whole, potentially increasing power (Neale & Sham 2004).
QTL of large effect will have changed most in frequency over time and will be most affected by the loss of power, whereas QTL that have changed little in frequency are likely to be of smaller effect and may be undetectable.
Similar(56)
One major QTL for ovary size was detected in each backcross, along with several smaller effects and two QTL for ovary asymmetry.
Large trial sample sizes generally produce smaller effects, and ours is the largest trial to date with a population in an at risk mental state.
Rather, a small tax cut should be expected to have a small effect — and at this point one worth seeking.
The Clinton administration has shot its bolt on the terrorist problem with small effect, and a flashy show of force during the next few months will not change the record.
It's a very small effect, and they admit that," says computational neuroscientist Roland Baddeley of the University of Bristol.
Traditional approaches to refined mapping are typically hampered by the small effect and the small proportion of the variance attached to individual QTLs.
Men scored higher on realistic (large effect, as defined by Cohen, 1988), investigative (small effect), and enterprising (large effect) interests, whereas women obtained higher scores on artistic (large effect) and social (large effect) interests.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com