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Smaller values of Ne and τ correspond to smaller disease progression times, i.e., the time for the CD4+ T cell count to drop below 200 copies/µL, and thus to faster disease progression.
From our findings, smaller disease lesions were observed in OsRap2.6 Ox plants as compared to the WT as shown in the photograph (Figure 8B), qPCR anlysis of fungal growth (p ≤ 0.01, n= 48) (Figure 8C) and relative lesion length (p ≤ 0.01, n= 48) (Figure 8D).
In addition, as the absolute effect difference becomes smaller because of a smaller disease burden in the absence of vaccination (ENV) the slope of the line steepens.
To increase power in EWAS using smaller disease cohorts, several methods have recently been developed to extend beyond single CpG analysis by leveraging concordant statistical signals from neighboring CpGs to identify DMRs [ 55, 77].
Non-communicable diseases cause only a slightly smaller disease burden per capita in LMIC than in HIC (IRF 0.8), demonstrating the double burden of communicable and non-communicable diseases in LMIC.
Several of the smaller disease groups (Additional file 1) reflect the hierarchy of MeSH headings which are used for BKL disease annotation, e.g. hepatitis descriptors (group 7), ataxias (group 14), osteoporosis and postmenopausal osteoporosis (group 21), and growth disorders and dwarfism (group 31).
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Even then, germ theorists like Joseph Lister struggled to persuade people that yet smaller disease-carriers existed.
While these studies demonstrate that arrays are an excellent tool for identifying DNA deletions, the density of oligonucleotides required to detect smaller disease-causing deletions remains unclear.
Nationally representative surveys, such as the National Health and Nutrition Examination Survey (NHANES) (13) and smaller disease-specific studies such as the Cardiovascular Health Study (14), serve important aims in providing population-based estimates of disease prevalence and incidence.
Gleevec went to market for a small disease, 50,000 patients, and it later got tested for other things.
As with all imaging there is some limit and small disease may be missed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com