They have evolved, and over time these small changes have accumulated into huge changes and represent the transformation of a group of mostly large, Earth-bound carnivores into a plethora of flying birds.
Therefore, small changes have a strong effect on similarity in fragments.
Note, however, that after 1997, a sequence of small changes have been progressively introduced (ending in the 2011-2013 reforms, which include quite substantial modifications of the parameters and the working of the system).
The changes in the conformations around main-chain and side-chain torsions of the two aspartates are very small, but these small changes have synergistically caused differences in the interaction distances, which could be significant.
However, Swedish ISAAC data indicate that only small changes have occurred over time in specific age groups, indicating small secular effects [ 5].
Small changes have been made to the protocol over time, to reflect changes in points of outcome data collection and recruitment procedures.
Note that this is a simplification of the underlying biology, as there are sometimes small insertions or deletions at breakpoints, but these small changes have limited effect on the analysis of larger structural variants.
These small changes had no effect on the separation and resolution of CTZ, PPA and NMS.
Multiresolution analysis has been performed varying the value of λ according to Equation 4. A logarithm scaling has been used for λ, as we experimentally found that small changes had a negligible impact on the corresponding algorithm for community detection.
Small changes had been made to the prescriptions of 24 subjects with or without schizophrenic disorders during the past six months; however, all patients were clinically judged to be stable enough to undergo the assessment by a responsible psychiatrist.
