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In both cases, the high-dose group saw smaller changes from baseline than the conventional group.
In general, patients receiving MTX at baseline had smaller changes from baseline to week 104 in total SHS compared with patients not receiving MTX, despite having more radiographic damage at baseline.
The smaller changes from baseline in back pain VAS and EQ-VAS in the prior bisphosphonate users may reflect a greater severity of osteoporosis in this group of patients, as shown by their baseline clinical risk factors.
The a priori ANCOVA did not show significant differences in radiographic progression between either groups 2 or 3 and group 1; however, in a post hoc analysis using normalised data, significantly smaller changes from baseline in erosion and total vdH S scores were seen in group 3 than in group 1.
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However, a noticeably smaller change from baseline to visit 2 was seen in the depressed laterocollis subgroup for 'emotional wellbeing' (−4.5) when compared with the depressed torticollis subgroup (−12.5).
Single polls are always dubious of course, and small changes from poll to poll don't usually mean a lot – they're just random noise.
Real history is the slow-crawl study of small changes, from clan loyalties to price ratios — gradually shifting tectonic plates that suddenly erupt into visible mountains.
As is usually the case with a Johns exhibition, the works in it are fundamentally a series in which small changes from work to work provide much of the pleasure.
Both periods predict no or small changes from 0 to 20 % in Northern Europe (i.e. European Russia, Poland and Scandinavian Peninsula) and Central-Eastern Europe (i.e. Germany, Austria, Switzerland, Hungary, Czech Republic, Slovakia, and Ukraine).
It is evident from the graph that the stress seismic waveforms and the water pressure seismic waveforms matched very well, including the small changes from the point of wave arrival to the succeeding waves.
For trigonal channels, T3 guests distort in two (planar and non-planar) configurations, depending on size factors of the nanochannels and small changes from the trigonal to orthorhombic symmetry favour the planar configuration of the guest molecule.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com