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Many studies have demonstrated the utility of PCR especially since multiplex testing can be performed on a very small volume of fluid [14, 15].
Hence, the performance effects associated with ingesting a comparably small volume of fluid (e.g. ≤0.75 L kg BM lost−1) or an amount consistent with recommended guidelines (e.g. 1.25 1.50 L kg BM lost−1) remains uncertain.
In Newtonian formulation, the number of molecules is so large ((^{sim }10^{23})) for a small volume of fluid in practice that it is practically impossible to describe the whole system with the most advanced computational techniques.
In intrauterine insemination, spermatozoa are inseminated in a small volume of fluid directly into the uterus.
Intranasal instillation involves the introduction of a small volume of fluid containing infectious microbes into the nares: Given sufficient fluid volume, instilled materials have been shown to move to the lungs [ 57, 58].
The first advantage of this test over the classical fluid challenge is obviously that such a small volume of fluid is unlikely to induce fluid overload [ 33], even if repeated several times a day.
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Although both dyes in the free form can penetrate intact skin to a limited extent [19,25,51] and MN-treated skin to a larger extent [10,25], contribution of the free form of the dyes to the observed fluorescence could be considered negligible in view of the limited dye release in the small volume of fluids at the skin surface.
The main issue with the mini-fluid challenge is that small volumes of fluid can only induce small changes in cardiac preload and, in patients with preload responsiveness, only small changes in cardiac output.
These tests are based on the principle of inducing short-term changes in cardiac preload, using heart lung interactions, the passive leg raise or by the infusion of small volumes of fluid, and to observe the resulting effect on cardiac output.
The magnetotelluric (MT) method involves the measurement of time-varying natural electromagnetic fields for the remote detection of small volumes of fluid or melt in the crust and upper mantle (e.g., Hill et al. [2009]; Wannamaker et al. [2009]; Ingham et al. [2009]; Aizawa et al. [2014]).
Applying even small volumes of fluid to the apical surface of HBECs induces fluid absorption [ 23].
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