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Dunn index [60] assigns greater values to sets of clusters that are compact and well-separated clusters with a small variance between members of the cluster.
Brown-Forsthye test shows that all pluripotency genes are expressed with small variance between different cell lines analyzed (p = 0.27) (Fig. 1C), whereas XIST expression varied significantly (p = 2.2×10−17) (Fig. 1D).
Overall test-retest reliability coefficients indicated substantial agreement for the VAS, with small variance between groups.
Subsequently, we identified a common subset of 341 genes among the 1,000 highest ranked genes in all three experiments with a small variance between the experiments.
The combination of a "small" variance between subjects and "large" costs associated with recruiting subjects also leads to the optimal sampling strategy being particularly sensitive to non-linearities in costs.
The approach designed for quantifying neuronal proportions was enabled by the large DNA methylation difference and small variance between neuronal and non-neuronal DNA methylation profiles at top CETS loci.
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Second, its seems important to note that electronic trading–which was originally heralded as the end of trading inefficiencies has, in the view of some traders, resulted in markets more segmented than in the old days where arbitrageurs were able to exploit small variances between the Pacific and New York exchanges.
However, small variances between the modelled values are magnified geometrically by the relationship between nucleotide and codon mutation frequencies, as per Additional File 2, and exponentially by the action of PCR amplification.
Scatterplots between replicates (Additional file 1) and correlation coefficients (Additional file 2) showed that the replicates were very similar to each other (r = 0.9930 - 0.9979 for RMA) and that RMA produced the smallest variance between replicates, particularly at low levels of expression.
The relative small sample size, and the small variance in MAE/RMSE between models may have led to the differing conclusions between the full sample and validation analysis.
Additional support for this statement is provided by the statistically significant difference between the relatively small variance of within-day measurements, as compared to the magnitude of between-days changes (Figure 3; p-value<0.001 for all treatment groups, Mann-Whitney U-test).
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